- Family clinic OPORA, Yekaterinburg

Contraindications

Prednisolone and dexamethasone cannot be included in the list of medications used, if the patient suffers from hypersensitivity to the composition components

Special caution should be shown with such a littleness as :. Ulcerative disease

Ulcerative disease

  • peptic disease;
  • diverticulitis;
  • gastritis;
  • anastomosis of the intestine;
  • systemic osteoporosis;
  • immunodeficiency.

The risk of negative consequences when taking dexamethasone is elevated if the patient's history is present by the pathology of endocrine and cardiovascular systems. A significant reason for concern is parasite infection. Dexamethasone is not recommended to drink (introduce) during pregnancy, during lactation. Another restriction can be a children's age.

Prednisolone also has "special" contraindications, among them:

Tuberculosis

  • tuberculosis;
  • kidney inflammation;
  • Incenko-Cushing disease;
  • syphilis;
  • Sugar diabetes (regardless of type).

In the risk group, the elderly, minor patients.

Recommended dosage for adult patients

Tablets must be littered with distilled water. They are swallowed completely. Chewing this medicine or make a crystalline powder from it is not recommended. Necessary taking time 6-8 in the morning. Minimum 2/3 of the daily dose must be taken early in the morning. It is at this time that the drug is increasing.

  • In serious diseases in severe patients, it is necessary to take at least 50-75 milligram drugs. This dose is identical to the reception of 10-15 pieces per day.
  • In chronic diseases it is recommended to take 20-30 milligrams, which is 4-6 tablets.
  • After the body comes to normal, the drug dosage must be reduced to 5-15 milligram per day.

The duration of therapy may be different. It is inherently dependent on the state of health of the patient and is appointed by a specialist.

The diluted powder for the preparation of intravenous solution, as well as the finished solution can be used both for adults and children. The necessary dose, the course of therapy and the introduction of the drug in the body appoints a specialist. Injections must be made from 6 to 8 am. Injections must be made precisely in the morning.

The recommended disposable dosage is 50-150 milliliters of the solution. When re-introducing the dosage should be the same. The interval of injections is 3-4 hours.

Ointment is applied by a thin layer on the skin with light massaging movements one or three times a day. The duration of treatment is from 6 to 14 days. As soon as the improvement comes, the use of the drug must be discontinued. It is forbidden to apply an armband from top of the gel. Otherwise, a large amount of drug can be bored in blood and cause the formation of side effects. Use the cure for more than two weeks is not recommended.

Eye drops need to be buried one or two drops three times a day. With acute diseases, it is necessary to produce injections every 2-4 hours. After surgical interventions, the drug can be applied only for the fifth day after the operation.

After improving the state therapy must be stopped.

Patient reviews

Margarita, 26 years old, Mozhaisk: "I have a keloid scars on my body, which look extremely not aesthetic. The doctor prescribed damas of Diprospan. I did them twice a day for 5 days. After that, during the week, the tablets of this medication took the tablets. The scars practically disappeared, no side effects arose. "

Oksana, 49 years old, Murmansk: “I have suffered from joint inflammation for a long time, because of which I could not move normally. The doctor prescribed Dexamethasone injections. The pain disappeared on the second day of treatment. After a course of therapy, I took 1 tablet 1 time per day for 2 weeks. As a result, the pain syndrome completely disappeared, while I did not observe any undesirable reactions of the body. "

Characteristics of Dexamethasone

Dexamethasone is a glucocorticosteroid agent that has a pronounced anti-inflammatory and anti-shock effect. Decreases the activity of cells of the immune system. It has a pronounced anti-toxic and anti-allergic effects.

The agent stimulates the formation of proteins that inhibit phospholipase-A2. Reduces the intensity of the formation of arachidonic acid and substances that provoke inflammation. The drug reduces the level of globulins, increases the synthesis of albumin in the kidneys.

Dexamethasone promotes the accumulation of fat in the face, abdomen, and shoulder girdle. Leads to a slight increase in the amount of blood cholesterol. Increases the amount of glucose by enhancing the release of this substance from the liver.

It is an antagonist of vitamin D, therefore it flushes calcium salts from bone tissue.

Prednisone or dexamethasone which is better for allergiesDexamethasone or Prednisolone is used to quickly relieve not only inflammatory processes, but also allergic reactions.

The drug is indicated for:

  • shock resistant to standard measures;
  • anaphylactic shock;
  • insufficient production of cortisol by the adrenal cortex due to a congenital disease of this organ, subacute inflammation of the thyroid gland;
  • pathologies of the adrenal axis;
  • edema of the brain caused by radiation injury, encephalitis, traumatic brain injury, tumor, neurosurgical intervention, hemorrhage and meningitis;
  • status asthmaticus;
  • pronounced narrowing of the lumen of the bronchi;
  • rheumatism;
  • severe allergic manifestations;
  • collagenoses (systemic lesions of connective tissues);
  • some malignant diseases (leukemia, lymphoma);
  • accumulation of calcium;
  • dermatosis;
  • some blood pathologies (thrombocytopenic idiopathic purpura, hemolytic anemia and agranulocytosis);
  • infectious diseases;
  • arthritis;
  • lupus erythematosus;
  • granuloma annular;
  • keloid scars.

Dexamethasone is contraindicated in:

  • pathological bleeding provoked by the use of anticoagulants;
  • joint plastic;
  • intra-articular fractures;
  • infection of the joint.

The medicine causes the following side effects:

  • metabolic disorders in the form of water retention, sodium, excessive excretion of potassium, increased appetite and deposition of excess subcutaneous fat;
  • intense blood clots;
  • arrhythmia, progression of heart failure;
  • digestive disorders, manifested in the form of nausea, an increase in the size of the liver, the appearance of ulcers on the mucous membrane of the stomach and intestines;
  • increased fatigue;
  • changes in the structure of the skin;
  • the development of steroid diabetes and Itsenko-Cushing's syndrome;
  • menstrual irregularities
  • delayed sexual development in children.

Prednisone or dexamethasone which is better for allergiesDexamethasone is contraindicated for: pathological bleeding provoked by the use of anticoagulants.

What is better Dexamethasone or Prednisolone

It is impossible to answer unequivocally which of these drugs is better without analyzing the patient's history. The choice of medication is carried out by the doctor based on the results of the diagnostic examination. Each of the drugs has a different dosage, if taken incorrectly, the effect will not come. It is necessary to study the compatibility of each of the drugs when choosing the optimal dose. The equivalent doses are selected by the doctor.

With osteochondrosis

For relief of pain caused by the inflammatory effect, it is better to prescribe Dexamethasone. Prednisolone in this case is used much less frequently.

For allergies

Dexamethasone for allergies is used if therapy with other drugs is ineffective. In most cases, this medication has a quick and strong enough effect.

With severe allergic reactions, the effect of Prednisolone is weak. Therefore, experts recommend starting treatment with Dexamethasone.

With asthma

In case of an asthma attack, doctors prescribe either Prednisolone or Dexamethasone. If long-term therapy is necessary, Dexamethasone is preferred.

In sports

Due to the action of Dexamethasone, the intensity of anabolism increases. Taking small doses of this drug (subject to intense training) provides a steady increase in muscle mass.

The minimum dosage of Prednisolone is 0.5-1.5 mg per day.

Which drug is better

Choosing which is better Dexamethasone or Prednisolone, you must adhere to the doctor's recommendations ... This is due to the fact that each of these drugs has a different dosage of the main substance. It is known that various drugs, which include natural hormones, act on the body in different ways. For example, hydrocortisone is 4 times weaker, and metipred or triamcinolone is 20% stronger than prednisolone. At the same time, Prednisolone is 7 times weaker than Dexamethasone and 10 times weaker than Betamethasone.

Stopping on one or another hormonal agent, the doctor will certainly take into account the degree of the disease and the general physical condition of the patient. Of course, for each specific case, the doctor will choose the appropriate medicine, but he will never recommend taking the drug Prednisolone with Dexamethasone.

Side effects

Negative effects after a short use are extremely rare. Basically, the consequences affecting human health are manifested in people prone to various allergic reactions. Long-term treatment can provoke deterioration in health and irreversible consequences. With prolonged use of the medication, the following may occur:

  1. In the digestive system: the development of stomach and colon ulcers, bleeding, nausea, gag reflex, increased appetite. The development of pancreatitis, esophagitis, and increased gas production can be observed.
  2. Side effects in the nervous system: there is an increase in intracranial pressure, provoking stagnation of the optic nerve head. Some patients have insomnia, migraine, dizziness, increased heart rate, convulsions, fainting, severe headache.
  3. In the endocrine system: the working capacity of the adrenal cortex is disrupted, growth retardation in adolescents, an increase in blood sugar. In girls, the cycle of critical days may fail, an increase in hair growth on the skin.
  4. A retention of salts and water in the body may occur, which provokes a violation of pressure and a malfunction in the work of hematopoiesis.
  5. Patients may feel weakness, fragility of bones, pain in the muscles, an increase in fractures, and vertebral displacement.
  6. On the skin, wound healing, the formation of erythema worsens. Increased sweating may occur. Adolescents develop acne, rash, dermatitis.
  7. Side effects in ophthalmology: patients develop cataracts, intraocular pressure increases. In especially severe cases, exophthalmos and glaucoma develop.
  8. A violation of nervous activity is formed. Patients have psychosis, depression, fear, irritation.
  9. A negative nitrogen balance may appear, which provokes the destruction of proteins. This interaction can lead to weight gain.
  10. There is a decrease in the number of leukocytes and platelets. At the same time, there is an increase in the level of calcium and cholesterol.
  11. Side effects with the development of allergies. Allergic reactions are formed, the development of anaphylactic shock, an increase in heart rate. People have skin rashes, hives, and blistering.

What is the difference between Dexamethasone and Prednisolone from each other

Despite a significant amount of overlap in prescriptions, therapeutic effects, contraindications and side effects, you can still find a difference in the properties of Prednisolone and Dexamethasone.

  • Duration of therapeutic action: Prednisolone retains its activity for 1-1.5 days, while Dexamethasone has a more prolonged effect - for up to 3-4 days.
  • Strength of effect on the body: Prednisolone is less powerful than an alternative remedy.
  • The mechanisms of the therapeutic action of the two drugs are different, which must be taken into account. Otherwise, ignorance of their specifics will provoke strong side effects and further complication of the patient's condition.
  • The difference between Prednisolone and Dexamethasone is in a different effect on the content of water and electrolytes in the body.
  • Dexamethasone strongly suppresses vit. D, which contributes to the deterioration of calcium absorption, accelerated excretion from the body. As a result, bone tissue becomes more fragile, creating conditions for the development or progression of osteoporosis.

Since the effect of Dexamethasone treatment lasts longer, it may replace Prednisolone. This will allow you to take the medicine less often while maintaining the therapeutic effect and at the same time reduce the likelihood of side effects.

In addition, Dexamethasone is more often prescribed for serious inflammatory pathologies, sepsis, manifestations of anaphylaxis, multiple sclerosis and other severe conditions.

In other situations, when the patient has problems with the state of blood vessels or tissues, trauma, fever, etc., doctors prefer to prescribe Prednisolone or use another analogue of Dexamethasone.

Which is better - Prednisolone or Dexamethasone

It is difficult to say which drug is better. They are not analogs of each other, they are 2 independent means with different mechanisms of action on the body. Medicines are prescribed by a doctor depending on the severity of the clinical case.

Prednisolone, which has a more gentle effect on the body, is recommended to be taken if the patient requires long-term treatment. Long-term use of Dexamethasone is not recommended due to the high risks of developing intense side effects.

Medicines have almost identical indications for use. Prednisolone is prescribed in such situations:

  • damage to blood vessels, connective tissue;
  • the development of polyarthritis;
  • fever of the rheumatoid type;
  • Addison's disease;
  • bronchial asthma;
  • inflammation of the eyes of an allergic nature;
  • anemia against the background of erythrocyte hemolysis;
  • acute course of pancreatitis or exacerbation of the chronic form of the disease;
  • the need to suppress immunity after transplantation of internal organs;
  • collapse;
  • toxemia;
  • peritonitis;
  • anaphylactic shock;
  • Quincke's edema and other acute shock conditions.

The indications for the appointment of Dexamethasone are almost identical, with a slight expansion of the list of clinical cases. Dexamethasone is preferred for the following conditions:

  • severe course of infectious diseases;
  • asthmatic status;
  • septicemia;
  • toxemia;
  • eclampsia;
  • peritonitis;
  • anaphylactic shock;
  • excessively intense reactions of the body of a pyrogenic nature.

Prednisone or dexamethasone which is better for allergiesDexamethasone is preferred for anemia associated with erythrocyte hemolysis. Dexamethasone has such an advantage as the possibility of using it by people who are involved in strength sports - powerlifting and bodybuilding. Dexamethasone shifts the metabolism to anabolism, due to which, even with extremely low doses of anabolic steroids or steroids, the process of building high-quality muscle mass is accelerated.

Indications for the use of Dexamethasone in sports are inflammation with damage to the ligaments, the need to increase physical endurance.

The use of this glucocorticosteroid promotes the fastest recovery from excessive physical exertion. In sports, Dexamethasone is approved for use in minimal doses and in a short course.

Both drugs perfectly relieve allergic manifestations with severe and intense symptoms. These drugs are prescribed equally often for anti-shock therapy due to such properties as a rapid increase in blood pressure.

Which is stronger?

Dexamethasone is 30 times stronger than Prednisolone, but such an effective action also carries high risks of side symptoms

Therefore, it is necessary to take this remedy with extreme caution and only in those cases when the intake of such a potent substance is required. Due to the fact that Dexamethasone is much stronger, it is difficult to find equivalent doses

Those. Dexamethasone is a drug that is used mainly in extremely severe cases when the patient's condition threatens his life and it is required to stabilize the condition as soon as possible. Prednisolone is preferably used as a long-term therapy agent.

Side effects

Negative effects after a short use are extremely rare. Basically, the consequences affecting human health are manifested in people prone to various allergic reactions. Long-term treatment can provoke deterioration in health and irreversible consequences. With prolonged use of the medication, the following may occur:

  1. In the digestive system: the development of stomach and colon ulcers, bleeding, nausea, gag reflex, increased appetite. The development of pancreatitis, esophagitis, and increased gas production can be observed.
  2. Side effects in the nervous system: there is an increase in intracranial pressure, provoking stagnation of the optic nerve head. Some patients have insomnia, migraine, dizziness, increased heart rate, convulsions, fainting, severe headache.
  3. In the endocrine system: the working capacity of the adrenal cortex is disrupted, growth retardation in adolescents, an increase in blood sugar. In girls, the cycle of critical days may fail, an increase in hair growth on the skin.
  4. A retention of salts and water in the body may occur, which provokes a violation of pressure and a malfunction in the work of hematopoiesis.
  5. Patients may feel weakness, fragility of bones, pain in the muscles, an increase in fractures, and vertebral displacement.
  6. On the skin, wound healing, the formation of erythema worsens. Increased sweating may occur. Adolescents develop acne, rash, dermatitis.
  7. Side effects in ophthalmology: patients develop cataracts, intraocular pressure increases. In especially severe cases, exophthalmos and glaucoma develop.
  8. A violation of nervous activity is formed. Patients have psychosis, depression, fear, irritation.
  9. A negative nitrogen balance may appear, which provokes the destruction of proteins. This interaction can lead to weight gain.
  10. There is a decrease in the number of leukocytes and platelets. At the same time, there is an increase in the level of calcium and cholesterol.
  11. Side effects with the development of allergies. Allergic reactions are formed, the development of anaphylactic shock, an increase in heart rate. People have skin rashes, hives, and blistering.

Despite a significant amount of overlap in prescriptions, therapeutic effects, contraindications and side effects, you can still find a difference in the properties of Prednisolone and Dexamethasone.

  • Duration of therapeutic action: Prednisolone retains its activity for 1-1.5 days, while Dexamethasone has a more prolonged effect - for up to 3-4 days.
  • Strength of effect on the body: Prednisolone is less powerful than an alternative remedy.
  • The mechanisms of the therapeutic action of the two drugs are different, which must be taken into account. Otherwise, ignorance of their specifics will provoke strong side effects and further complication of the patient's condition.
  • The difference between Prednisolone and Dexamethasone is in a different effect on the content of water and electrolytes in the body.
  • Dexamethasone strongly suppresses vit. D, which contributes to the deterioration of calcium absorption, accelerated excretion from the body. As a result, bone tissue becomes more fragile, creating conditions for the development or progression of osteoporosis.

Since the effect of Dexamethasone treatment lasts longer, it may replace Prednisolone. This will allow you to take the medicine less often while maintaining the therapeutic effect and at the same time reduce the likelihood of side effects.

In addition, Dexamethasone is more often prescribed for serious inflammatory pathologies, sepsis, manifestations of anaphylaxis, multiple sclerosis and other severe conditions.

In other situations, when the patient has problems with the state of blood vessels or tissues, trauma, fever, etc., doctors prefer to prescribe Prednisolone or use another analogue of Dexamethasone.

Dexamethasone or Prednisolone - which is better? Shocking truth!

It is difficult to say which drug is better. They are not analogs of each other, they are 2 independent means with different mechanisms of action on the body. Medicines are prescribed by a doctor depending on the severity of the clinical case.

Prednisolone, which has a more gentle effect on the body, is recommended to be taken if the patient requires long-term treatment. Long-term use of Dexamethasone is not recommended due to the high risks of developing intense side effects.

Medicines have almost identical indications for use. Prednisolone is prescribed in such situations:

  • damage to blood vessels, connective tissue;
  • the development of polyarthritis;
  • fever of the rheumatoid type;
  • Addison's disease;
  • bronchial asthma;
  • inflammation of the eyes of an allergic nature;
  • anemia against the background of erythrocyte hemolysis;
  • acute course of pancreatitis or exacerbation of the chronic form of the disease;
  • the need to suppress immunity after transplantation of internal organs;
  • collapse;
  • toxemia;
  • peritonitis;
  • anaphylactic shock;
  • Quincke's edema and other acute shock conditions.

The indications for the appointment of Dexamethasone are almost identical, with a slight expansion of the list of clinical cases. Dexamethasone is preferred for the following conditions:

  • severe course of infectious diseases;
  • asthmatic status;
  • septicemia;
  • toxemia;
  • eclampsia;
  • peritonitis;
  • anaphylactic shock;
  • excessively intense reactions of the body of a pyrogenic nature.

Dexamethasone is preferred for anemia associated with erythrocyte hemolysis.

Dexamethasone has such an advantage as the possibility of using it by people who are involved in power sports - powerlifting and bodybuilding. Dexamethasone shifts the metabolism to anabolism, due to which, even with extremely low doses of anabolic steroids or steroids, the process of building high-quality muscle mass is accelerated.

Indications for the use of Dexamethasone in sports are inflammation with damage to the ligaments, the need to increase physical endurance.

The use of this glucocorticosteroid promotes the fastest recovery from excessive physical exertion. In sports, Dexamethasone is approved for use in minimal doses and in a short course.

Both drugs perfectly relieve allergic manifestations with severe and intense symptoms. These drugs are prescribed equally often for anti-shock therapy due to such properties as a rapid increase in blood pressure.

Which is stronger?

Dexamethasone is 30 times stronger than Prednisolone, but such an effective action also carries high risks of side symptoms

Therefore, it is necessary to take this remedy with extreme caution and only in those cases when the intake of such a potent substance is required. Due to the fact that Dexamethasone is much stronger, it is difficult to find equivalent doses

Those. Dexamethasone is a drug that is used mainly in extremely severe cases when the patient's condition threatens his life and it is required to stabilize the condition as soon as possible. Prednisolone is preferably used as a long-term therapy agent.

In order to compare drugs, you need to know how they work. Both drugs are able to affect the exchange of proteins within the body, increase the rate of insulin production and normalize the work of the pituitary gland. The active ingredients block histamine, preventing the development of allergies.

Similarity

In addition to partially identical indications for use, Dexamethasone and Prednisolone have similar contraindications. These include:

  • open form of tuberculosis;
  • high blood cholesterol levels;
  • the presence of fatty plaques inside the vessels;
  • AIDS;
  • the last stage of obesity;
  • pathology of the urinary tract (including urolithiasis);
  • ulcerative lesions of the stomach and duodenum;
  • insulin dependence in diabetes mellitus;
  • heart, kidney, or liver failure;
  • lichen (pink, shingles);
  • Itsenko-Cushing's disease.

With an incorrectly selected dosing regimen, the risk of side effects increases. The frequency of manifestations can be influenced by the incorrect ratio of the dosage regimen, course and method of application. Side effects include:

  • fluid and sodium retention in the body, hyperglycemia, hypokalemia, glucosuria;
  • secondary hypopituitarism and hypocorticism;
  • menstrual irregularities in women;
  • blood pressure surges;
  • hypercoagulability, thrombosis;
  • obliterating endarteritis;
  • steroid myopathy, aseptic necrosis, muscle weakness.

We suggest that you familiarize yourself with: Alcohol and male potency: the effect, is it possible to restore Dexamethasone is not prescribed with an increased level of cholesterol in the blood.

Most often, patients experience ailments from the digestive tract. The patient complains of pain in the epigastric region, heartburn, bouts of nausea and vomiting. In most cases, the ailment goes away on its own. Running situations require symptomatic treatment.

Both medicines are incompatible with alcohol. Driving a car and other vehicles is allowed.

What is the difference?

The difference between the 2 drugs lies in their mechanism of action. Prednisolone accelerates the elimination of potassium and calcium from the body, which increases the risk of sodium and fluid retention in the body. Regular use of Dexamethasone disrupts the water-salt balance.

The drugs are not considered full substitutes for each other, so you need to consult a doctor in a timely manner.

Prednisolone is much weaker than Dexamethasone: it acts milder, without provoking ailments from the cardiovascular, digestive and nervous systems.

Which is stronger?

There is no unequivocal answer to the question which is better: Prednisolone or Dexamethasone. Despite approximately the same contraindications for use and some similarity of the compositions, medicines can affect the patient's body in different ways. According to research results, side effects are extremely rare with regular use of Prednisolone.

The cost of medicines varies depending on the form of release and the place of sale. Prednisolone:

  • drops - from 120 rubles;
  • ointment - from 80 rubles;
  • tablets - from 95 rubles;
  • injections - from 120 rubles. per packing.
  • When taken simultaneously with salicylates, the risk of bleeding increases;
  • Diuretics disrupt electrolyte balance;
  • Hypoglycemic drugs reduce the amount of glucose;
  • Glycosides cause intoxication;
  • Hypotensins cause a weakening of the effect of the drug;
  • Somatropins cause a decrease in absorption;
  • If you combine oral contraceptives containing estrogen, an increase in the effectiveness of the drug may occur;
  • Carbutamide and azathioprine are at risk of developing cataracts;
  • Nitrates and M-anticholinergics increase intraocular pressure;

Comparison of Prednisolone and Dexamethasone

In order to compare drugs, you need to know how they work. Both drugs are able to affect the exchange of proteins within the body, increase the rate of insulin production and normalize the work of the pituitary gland. The active ingredients block histamine, preventing the development of allergies. Under the influence of glucocorticosteroids, the rate of tissue scarring slows down.

Similarity

In addition to partially identical indications for use, Dexamethasone and Prednisolone have similar contraindications. These include:

  • open form of tuberculosis;
  • high blood cholesterol levels;
  • the presence of fatty plaques inside the vessels;
  • AIDS;
  • the last stage of obesity;
  • pathology of the urinary tract (including urolithiasis);
  • ulcerative lesions of the stomach and duodenum;
  • insulin dependence in diabetes mellitus;
  • heart, kidney, or liver failure;
  • lichen (pink, shingles);
  • Itsenko-Cushing's disease.

With an incorrectly selected dosing regimen, the risk of side effects increases. The frequency of manifestations can be influenced by the incorrect ratio of the dosage regimen, course and method of application. Side effects include:

  • fluid and sodium retention in the body, hyperglycemia, hypokalemia, glucosuria;
  • secondary hypopituitarism and hypocorticism;
  • menstrual irregularities in women;
  • blood pressure surges;
  • hypercoagulability, thrombosis;
  • obliterating endarteritis;
  • steroid myopathy, aseptic necrosis, muscle weakness.

Prednisone or dexamethasone which is better for allergiesDexamethasone is not prescribed for elevated blood cholesterol levels. Most often, patients experience ailments from the digestive tract. The patient complains of pain in the epigastric region, heartburn, bouts of nausea and vomiting. In most cases, the ailment goes away on its own. Running situations require symptomatic treatment.

Both medicines are incompatible with alcohol. Driving a car and other vehicles is allowed.

What is the difference?

The difference between the 2 drugs lies in their mechanism of action. Prednisolone accelerates the elimination of potassium and calcium from the body, which increases the risk of sodium and fluid retention in the body. Regular use of Dexamethasone disrupts the water-salt balance.

Compositional similarities

The most common forms are ampoules and tablets. The former contain 25 and 30 milligrams and 1 ml. Comes in a pack of three. There are also ampoules with 1 ml of suspension specifically for injection or injection. They contain 25 and 50 milligrams. In a package, there can be from 5 to 1000 pieces. There is also an ointment in tubes, a solution and even eye drops. But the most popular are tablets in packs of one hundred.

For example, in one tablet from the manufacturer Nycomed and Gedeon Richter - 0.005 grams of prednisolone, there are also such excipients as milk sugar, calcium stearate and potato starch.

How much is?

The aforementioned form of release will cost the patient about 150 rubles, while a 1-millimeter ampoule will cost 100 rubles.

It is prescribed for a whole list of diseases: collagenosis, rheumatoid arthritis, polyarthritis, asthma, leukemia, mononucleosis, neurodermatitis, eczema, allergies, adrenal insufficiency, anemia, pancreatitis, collapse and shock, conjunctivitis, blepharitis, inflammation of different parts of the eye, as well as after trauma to the organs of vision.

Analogues are cheaper

How to replace this medicine? The only more or less common analogs for this drug are called Decorin, Medrol, Deltason. Also in pharmacies you can find such a substitute as Metipred.

Metipred or prednisolone, which is better?

There is no unequivocal answer to the question which is better. Both drugs are good enough to cope with their assigned functions. Consult your doctor before your appointment, and he will individually prescribe one of these drugs.

The main difference and differences between these largely similar drugs are side effects. Therefore, some people tolerate prednisolone better than others - methylprednisolone. Another important difference is cost. Here, plus it is worth putting it on prednisolone.

The active substance in Hydrocortisone is hydrocortisone acetate. The basis of a glucocorticoid for systemic and local use is the substance prednisolone. It is a dehydrated analogue of hydrocortisone. Both drugs are derivatives of cortisone, a hormone of the adrenal cortex in humans. The similarity in the compositions of the drugs is due to their common origin.

Interaction with other drugs

  • When taken simultaneously with salicylates, the risk of bleeding increases;
  • Diuretics disrupt electrolyte balance;
  • Hypoglycemic drugs reduce the amount of glucose;
  • Glycosides cause intoxication;
  • Hypotensins cause a weakening of the effect of the drug;
  • Somatropins cause a decrease in absorption;
  • If you combine oral contraceptives containing estrogen, an increase in the effectiveness of the drug may occur;
  • Carbutamide and azathioprine are at risk of developing cataracts;
  • Nitrates and M-anticholinergics increase intraocular pressure;

General information about drugs

Dexamethasone and Prednisolone belong to the group of strong hormonal drugs of synthetic origin. They are used to treat acute asthma attacks. The main principle of drug action is to suppress the body's immune response to an existing stimulus.

Preparations of this group, created on the basis of the adrenal cortex hormone, are used in such cases:

  • In the form of substitution therapy. The use of drugs provides a decrease in the level of natural glucocorticosteroids in the body;
  • For super-dull therapy. The drugs stop the production of other hormones by the brain;
  • For pharmacodynamic effects. The use of medicines provides relief of certain negative symptoms of asthma or allergies.

In most cases, with injuries or pathologies of blood vessels and tissues, doctors prefer the drug Prednisolone. It is also more often used in the case of a patient with a fever of unknown etiology, contagious mononucleosis, anemia, states of shock and in case of exacerbation of pancreatitis.

Prednisone

The drug of the glucocorticosteroid group Prednisolone is considered a drug of medium duration. The high efficiency of the drug is due to its ability to block the activity of macrophages and leukocytes, as well as not let them pass to the focus of the inflammatory process. Also, Prednisolone stops the processes of absorption and accentuation of inflammatory mediators, intergleukin.

Prednisone or dexamethasone which is better for allergiesPrednisone

The drug stimulates the breakdown of fats, preventing cells from absorbing glucose, and thus, the drug helps to stimulate the metabolism in the patient's body. However, a negative consequence of this can be an increased production of insulin, which often leads to an accelerated accumulation of fat in the body.

The use of Prednisolone leads to an intensive change in the water-salt balance in the patient's body. Calcium and potassium are actively removed from the patient's body. At the same time, fluid retention in the body and an increase in sodium concentration occur.

In terms of its effectiveness, Prednisolone is 4 times stronger than the natural adrenal hormone, hydrocortisone. This effect occurs due to the minimization of basophils in the body.

Dexamethasone

The synthetic glucocorticosteroid Dexamethasone is a long-term drug. For this reason, it is extremely rarely used when long-term treatment is required.

When ingested, Dexamethasone contributes to a significant increase in the amount of fatty acids, blood cholesterol and triglycerides. Due to this effect on the biochemistry of the human body, taking Dexamethasone is associated with the risk of developing hyperglycemia. Therefore, it is highly undesirable for patients with diabetes mellitus and pregnant women to use it.

The drug practically does not affect the water-salt balance of the body and the level of electrolytes.

Prednisone or dexamethasone which is better for allergiesDexamethasone

Dexamethasone is 10 times more effective than the natural human adrenal hormone. In this case, the relief of inflammatory processes in the patient's body occurs by increasing the stability of the membranes, due to the effect on the obesity of cells and eosinophils.

Similarity of drugs

It is often difficult to say right off the bat that Dexamethasone or Prednisolone is better, since both of these drugs belong to the same category of drugs - glucocorticosteroids, i.e. natural substances produced by the adrenal cortex.

They share a number of similar characteristics:

  • Unlike natural hormones, both Dexamethasone and Prednisolone are more active at lower doses;
  • They have an equally good anti-inflammatory effect on the body;
  • They relieve allergic manifestations well due to the ability to release histamine from mast cells;
  • They have an anti-toxic effect;
  • The immunosuppressive properties of both drugs are equally effective in reducing the disturbances of the body's immune system;
  • Used in anti-shock therapy because they greatly increase blood pressure;
  • They are used for the same indications.

Dexamethasone and Prednisolone are widely used both in the provision of emergency care and in the fight against systemic diseases.

General information about drugs

Prednisone

The drug is a hormonal agent with a powerful anti-inflammatory effect. Included in the group of medium-acting agents. A pronounced therapeutic effect is achieved due to the active substance of the same name, which has a powerful anti-inflammatory and antiallergic effect. Prednisolone effectively relieves the intensity of inflammation by neutralizing the activity of leukocytes and microphages present in the tissues. At the same time, the substance prevents the migration of leukocytes to the focus of inflammation, blocks the processes of phagocytosis in macrophages, and suppresses the synthesis of the inflammatory mediator interleukin-1 in the body.

In addition, prednisolone has a positive effect on the state of cell membranes, as a result of which they become stronger, and pass inflammation enzymes into the inner space less. The permeability of capillaries affected by the release of histamine, the culprit of allergic reactions, improves.

The popularity of Prednisolone is explained by the many pharmaceutical varieties: the drug is produced by various manufacturers in the form of tablets, solutions for injections, ointments for the skin and eyes, drops, creams.

The indications for the appointment are:

  • Allergic and inflammatory diseases
  • Cerebral edema
  • BA, status asthmaticus
  • Systemic connective tissue diseases
  • Worsening adrenal insufficiency
  • Shocks that do not respond to other medications
  • Hepatic coma, acute form of hepatitis
  • Diseases of the digestive tract, hematopoiesis, eyes
  • Prevention of tissue rejection after transplantation.

A feature of Prednisolone is the ability to strongly influence the water-salt content: the drug accelerates the excretion of calcium and potassium, while inhibiting the excretion of sodium and water. As a result, the patient develops tissue edema.

Antiallergic action of Prednisolone is more powerful than that of hydrocortisone - more than 4 times.

Dexamethasone

GCS based on dexamethasone - a derivative of fluoroprednisolone, which has similar mechanisms of action as prednisolone. The medicine also helps with inflammatory processes and exacerbations, has antiallergic, anti-shock, anti-toxic and desensitizing effects. Like any corticosteroids, it suppresses the immune system. Dexamethasone is 10 times more active than endogenous cortisone. The drug promotes the active elimination of calcium, magnesium and potassium from the body. The anti-inflammatory effect is achieved through the mechanism of suppression of eosinophils and mast cells, strengthening of cell membranes. The drug increases the level of triglycides, fatty acids, cholesterol. Its peculiarity is that the drug is capable of provoking hyperglycemia.

Dexamethasone is not prescribed for long-term courses, since it has a long-term effect.

Dexamethasone analogs

In the presence of contraindications, the occurrence of undesirable reactions, and other factors, the question of how to replace Dexamethasone is relevant. The reason for the selection of an analogue, the selected drug must be agreed with the doctor and a prescription must be written for purchase at the pharmacy.

Drugs that can replace Dexamethasone with indication of approximate prices and country of origin

Analogue Release form Price, in rubles The country of manufacture
Dexamethasone injections 60-270 Russia, Belarus, Romania, Poland, Slovenia
pills 25-100
eye drops 30-300
Dexalgin pills 300-400 Italy or Spain
injections 240-600
granules 260-390
Hydrocortisone ointment 25-70 Russia
eye ointment 50-180
ampoules 180-300
Diprospan injection 170-250 Belgium
Metipred tablets and solution for injection 190-400 Finland
Diclofenac ampoules, tablets, candles 20-120 Russia, Slovenia
Maxidex drops 300-430 Belgium

Dexalgin

The imported non-hormonal analogue of Dexamethasone is Dexalgin. It belongs to the group of non-steroidal anti-inflammatory drugs, available in tablets and granules for oral administration, injections. It has several actions: reduces inflammation, relieves pain. Dispensing rules depend on the form: medicine for internal use - without a specialist's prescription, injections - with a prescription.

We suggest that you familiarize yourself with: Pimafucin for candidiasis of the intestines of the oral cavity of the genital organs tablets candles cream

Which is better - Dexamethasone or Dexalgin, depends on the indications, the patient's condition. Perhaps a joint appointment with the ineffectiveness of some NSAIDs.

Diclofenac

Analogue Diclofenac belongs to the group of NSAIDs. It has a pronounced analgesic and anti-inflammatory effect. Available in ampoules and tablets, suppositories.

Which is better - Diclofenac or Dexamethasone, depends on the patient's condition. In the acute form and ineffectiveness of NSAIDs, a glucocorticosteroid is prescribed. Simultaneous use with a doctor's prescription is possible.

Maxidex

An analogue of Dexamethasone eye drops is an imported drug Maxidex. Manufactured in Belgium, has the same indications and limitations. Other substitutes are Russian Dexoftan, Oftan Dexamethasone (Finland), Dexamethasonlong (Russia). Differs in quality and manufacturer of raw materials, manufacturing company, storage conditions. Often, domestic eye drops must be stored in the refrigerator.

Application methods

The dose is always selected individually

It is important to remember that glucocorticosteroids are strong substances, so only a qualified specialist can prescribe a course of treatment. Taking medications should be supervised by a doctor.

The average dose of Prednisolone during acute conditions is approximately 20-30 mg, which are distributed in several doses throughout the day. The introductory dosage can also be as high as 30 mg. With further use, the amount of Prednisolone should not exceed 5-10 mg. Children's dosage is 1 mg per 1 kg of body weight.

Learn about the treatment of brain neuroma. What are glucocorticoids prescribed for?

Read how myasthenia gravis manifests itself in children and what is prescribed for the disease.

All about the treatment of multiple sclerosis: groups of medications, the role of antibiotics in treatment.

During emergency situations, for example, with shock or cerebral edema, it is allowed to increase a single dose to 60–90 mg. In such cases, Prednisolone is injected into the body using a dropper or slowly in a stream.

At the beginning of the disease or during an exacerbation, a large amount of Dexamethasone is used, but then it is gradually reduced. For example, in multiple sclerosis, Dexamethasone is dropped at a dosage of 10–20 mg initially, and on the third day the dose is reduced to 2–5 mg. Unlike Prednisolone, this drug is used in smaller quantities. Usually the average dose is 2-4 mg.

During prolonged use of GCS, it is recommended to carefully monitor the electrolyte-water state of the body. It is also advisable to regularly take blood, urine and feces tests.

It is especially worth paying attention to the patient's sugar level. Usually, to prevent hypokalemia, potassium supplements are prescribed concurrently with glucocorticoids.

Important! It should be remembered that you should stop taking the drug very carefully and gradually in order to avoid withdrawal syndrome. ...

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Indications for use

Diprospan is used in the treatment of various diseases. It can be part of medicinal blockades for the relief of acute pain. This remedy is prescribed as part of complex therapy for the following pathologies:

  • attacks of sciatica, bursitis, lumbago;
  • osteoporosis, fasciitis, rheumatoid arthritis;
  • allergic rhinitis, dermatitis;
  • bronchial asthma;
  • photodermatitis, lichen planus, atopic and contact dermatitis;
  • eczema, psoriasis, cystic acne;
  • periarteritis nodosa, lupus erythematosus.

With scaly lichen, external preparations are more often used. But in the case of a worsening of the patient's condition, the occurrence of inflammation, the appearance of fluid on the plaques, diprospan from psoriasis is shown in the form of injections. It produces a powerful anti-inflammatory effect that is prolonged. Betamethasone in Diprospan is easily absorbed, so the medicine starts working quickly.

Read here how to treat scaly lichen in children, how to get rid of white spots on the skin after psoriasis, which causes pink and asbestos lichen in humans.

For the psychosomatic causes of rashes on the body, what happens to a person who is susceptible to the disease, see our material - psoriasis psychosomatics.

Where does psoriasis come from and how it can be treated read here - the causes of psoriasis.

Diprospan cannot be used by patients with psoriasis if they also suffer from:

  • diabetes mellitus;
  • high blood pressure;
  • mental illness;
  • purulent skin lesions caused by infection;
  • individual hypersensitivity to the components of Diprospan;
  • tuberculosis;
  • a stomach ulcer or gastritis;
  • thrombosis;
  • disorders of the heart;
  • oncological diseases;
  • kidney disease.

Diprospan or prednisone which is better

Indications for the use of the medication depend on the form of release:

  1. drops are prescribed for installations in the eyes for inflammatory diseases of the organ of vision (iritis, conjunctivitis, blepharitis, keratitis, etc.), for the prevention of postoperative complications;
  2. intramuscular and intravenous injections are used more often in emergency cases or for a long time in severe conditions: serious allergic reactions, cerebral edema with a brain tumor, shock, infectious diseases, diseases of the joints of an inflammatory-degenerative nature, etc.;
  3. the tablet form is used for bronchial asthma, acute eczema, after injections with a tumor and cerebral edema, exacerbation of rheumatoid arthritis, blood diseases, etc.

All forms of release are implemented strictly according to the doctor's prescription and a specially prepared prescription.

The method and features of the application are determined by a specialist. Injections are used at the beginning of treatment, usually up to 4 days by intramuscular, intravenous or intra-articular injection. The dosage of the tablets is selected by the doctor and is divided into 3-4 doses. If the tablets are taken once, the best time to take is in the morning.

The course of glucocorticosteroid therapy is individual. During treatment, it is necessary to regularly monitor blood pressure indicators, take blood tests, monitor the content of electrolytes in the blood and the level of glycemia.

With a sudden cessation of drug use, a withdrawal syndrome develops, characterized by increased symptoms, anorexia, weakness, musculoskeletal pain, lethargy and nausea.

The medicine is applied during or after meals. The dosage regimen is determined by a specialist.

The drug is injected intramuscularly slowly. Also possible routes of administration are intra-articular and intravenous (drip or stream).

One of the common questions of buyers, Dexamethasone - a painful injection or not. Painful sensations are possible during the introduction and after the injection, does not contain local anesthetics.

When it is better to inject Dexamethasone - in the morning or in the evening, you should check with your doctor based on the number of injections per day. It is not necessary to additionally dilute Dexamethasone injections, unless otherwise instructed by a specialist.

Prednisolone and Dexamethasone are drugs from the group of glucocorticosteroids, made on the basis of a natural hormone. Used in the treatment of severe allergies.

Prednisolone and Dexamethasone are used in the treatment of severe allergies

Prednisolone and Dexamethasone are used in the treatment of severe allergies.

Drug similarities

Medicines have many characteristics in common:

  1. They show high efficiency at minimal dosages in comparison with other medicines, which contain natural hormones.
  2. Dosage forms: available in the form of a solution for injection, ophthalmic drops, tablets and ointments.
  3. They have a wide range of effects and have a pronounced anti-inflammatory effect.
  4. They are used in the treatment of allergic manifestations and negative reactions from the immune system: with bronchial asthma, hepatitis and autoimmune diseases, infectious-allergic diseases of the joints,
  5. They are used in anti-shock therapy.
  6. The mechanism of influence. They increase blood pressure, block the production of the substance histamine, due to which allergic manifestations are quickly stopped. They have anti-inflammatory, anti-edematous and immunosuppressive effects.
  7. Do not take during breastfeeding. If necessary, lactation should be temporarily stopped.

Prednisolone and Dexamethasone can be used both as an emergency aid and in systematic therapy. For the latter, Dexamethasone is used in a minimum dosage due to the high risk of developing side effects.

Prednisolone has a pronounced anti-inflammatory effect

Prednisolone has a pronounced anti-inflammatory effect.

What is the difference?

There are some differences between medicines:

  1. Composition. The active ingredient of Prednisolone is prednisolone sodium phosphate, Dexamethasone is dexamethasone sodium phosphate.
  2. They have the opposite effect on the water-salt balance. Prednisolone promotes the active excretion of potassium and calcium, which causes fluid retention in the body. Dexamethasone does not possess such properties.
  3. Prednisolone rarely causes the development of side signs, while they are mild. In this regard, it is more preferable for long-term therapy.
  4. Possibility to take during pregnancy. In this case, preference is given to Prednisolone, as a safer drug. Dexamethasone can be prescribed only if there are special indications for this, and only as a drug for a single use.
  5. Duration of action of active ingredients. Prednisolone after administration lasts from 24 to 36 hours with a gradual decrease in activity. Dexamethasone lasts 72 to 96 hours.

Prednisolone is not a structural analogue of Dexamethasone, both drugs have a different composition and differ in their influence on some biochemical processes in the body. But the difference between the medicines does not prevent them from being used in the same clinical cases.

Which is better - Prednisolone or Dexamethasone?

It is impossible to say which remedy is better. The choice of this or that medication depends on a number of factors, the duration of therapy and the individual characteristics of the organism. If there is a need for long-term use of glucocorticosteroids, preference is given to Prednisolone as a milder and safer drug that rarely causes negative reactions in the body.

Dexamethasone is used more often in severe pathology when urgent assistance is required

Dexamethasone is used more often in severe pathology, when urgent assistance is required.

Dexamethasone is used more often in severe pathology, when urgent assistance is required. Also, this medicine is preferable for angioedema, bronchial asthma, sepsis and peritonitis, anaphylactic reactions. In addition, Dexamethasone is prescribed as a more potent agent in the treatment of multiple sclerosis and intense inflammatory processes.

Prednisolone is recommended to be taken for injuries and pathological changes in blood vessels and soft tissues, in case of febrile conditions of various etiologies, anemia, shock, if inflammation occurs when the ligaments are damaged.

Which is stronger?

Which glucocorticosteroid to choose - Prednisolone or Dexamethasone, is decided only by the doctor, based on the severity and intensity of the clinical case.

Prednisolone is recommended for long-term use, since it is 7 times weaker than Dexamethasone.

Due to its greater effectiveness and activity, Dexamethasone provokes manifestations of side reactions. Despite the fact that both medicines quickly stop allergic manifestations, dexamethasone therapy is prescribed only if there are special indications for it, for short-term therapy. After improving the general condition of the body, it is recommended to switch to a milder and safer Prednisolone.

Contraindications

Prednisolone is prohibited from taking in the following cases:

  • acute and chronic diseases of the digestive system;
  • renal failure;
  • liver failure;
  • diabetes;
  • pathological processes of various types arising against the background of HIV infection;
  • Itsenko-Kushchenko's disease;
  • recently transferred infectious diseases: measles, exacerbation of herpes, chickenpox;
  • rehabilitation period after a heart attack.

Contraindications to the use of Dexamethasone:

  • high concentration of cholesterol in the blood;
  • open form of tuberculosis;
  • peptic ulcer of the stomach or duodenum;
  • diabetes;
  • shingles;
  • obesity;
  • urolithiasis;
  • AIDS;
  • lack of any internal organ.

Both drugs are prohibited from taking in the presence of individual intolerance to individual components in the composition.

Overdoses of drugs are treated symptomatically. There are no specific antidotes. After symptomatic therapy, an adjustment of the doses of medications is required.

How to use?

Dosages of drugs are determined individually, depending on the severity of the pathology, age and weight of the patient:

  1. Prednisolone - from 20 to 30 mg per day, divided into several doses. The solution is administered intramuscularly and intravenously. As the patient's condition improves, the dosage is reduced to 5-10 mg. The dose for children is 1 mg per kilogram of body weight. Equivalent doses are prescribed when taking the tablet form of the medication.
  2. Dexamethasone in tablet form - 15 mg per day. Intravenous or intramuscular injection of an injection solution - from 0.5 to 9 mg, divided into several doses. The dosage during therapy can vary up or down, depending on the severity of the disease and the improvement in the general condition of the patient.

Side effects

A negative reaction of the body against the background of taking Prednisolone occurs during prolonged therapy and is manifested:

  • rapid weight gain up to obesity;
  • the development of hemorrhagic pancreatitis;
  • failure of the menstrual cycle;
  • suppression of the immune system;
  • disorders of the digestive system;
  • increased blood clotting;
  • disorders of the digestive tract.

Side signs that appear against the background of the use of Dexamethasone:

  1. From the side of the heart and vascular system: inflammation of the walls of blood vessels, arrhythmia, the appearance of heart failure.
  2. From the gastrointestinal tract: the formation of ulcers or erosions in the stomach, nausea and vomiting, an increase in liver volume, inflammation in the esophagus, the appearance of pancreatitis.
  3. Skin: thinning of the skin, acne, increased sweating, stretch marks.
  4. Central nervous system: increased fatigue and drowsiness, headaches, seizures, mental disorders.
  5. Endocrine disorders: obesity, menstrual irregularities, the appearance of body hair, the development of diabetes mellitus.
  6. Other side signs: allergy to the skin, development of non-infectious suppuration, pigmentation may appear at the injection site. Long-term use of the medication can lead to the development of osteoporosis.

In the ratio of the occurrence of side signs for taking glucocorticosteroids, Prednisolone shows greater safety.

Conditions of dispensing from pharmacies

Glucocorticosteroids are sold with a prescription from a doctor.

Price

The cost of Dexamethasone is from 20 to 230 rubles, Prednisolone is from 110 rubles.

Testimonials

Anna, 59 years old, Chelyabinsk

After undergoing several courses of chemotherapy, he developed extensive edema, nausea and vomiting. To eliminate these signs, Prednisolone was prescribed. But for several days of its introduction, a positive result was not observed. Transferred to Dexamethasone. This drug literally saved me. The first improvements appeared after the first injection. At first, high dosages were injected, which were gradually reduced. Within a week from the beginning of the course of treatment, the condition became much better. There was no trace of the side effects of chemotherapy.

Tamara, 28 years old, Moscow

At the age of 7, my daughter developed a severe allergy in the form of urticaria. None of the topical medications and antihistamines helped. We got an injection of Dexamethasone. After him, the child's condition first improved, but then side reactions began to appear. Replaced it with Prednisolone. He helped a lot. After 2 injections, they were transferred to a tablet form. Within a few days, the hives and other signs of allergies disappeared.

Kirill, 48 years old, Novgorod

I had some neurological disorders. First, Prednisolone was prescribed as a safer drug. But I did the opposite. This glucocorticosteroid provoked a severe allergic reaction. Dexamethasone helped with allergies and neurological disorders. Although they said that it often causes side symptoms, it did not cause any negative reactions in me. And he coped with my problem quickly.

Dexamethasone or Prednisolone is used in severe and life-threatening conditions. They are synthetic drugs, the most powerful steroids used to quickly stop not only inflammatory processes, but also allergic reactions. When used correctly, they do not cause side effects.

Characteristics of Dexamethasone

Dexamethasone is a glucocorticosteroid that has a pronounced anti-inflammatory and anti-shock effect. Decreases the activity of cells of the immune system. It has a pronounced anti-toxic and anti-allergic effects.

The agent stimulates the formation of proteins that inhibit phospholipase-A2. Reduces the intensity of the formation of arachidonic acid and substances that provoke inflammation. The drug reduces the level of globulins, increases the synthesis of albumin in the kidneys.

Dexamethasone promotes the accumulation of fat in the face, abdomen, and shoulder girdle. Leads to a slight increase in the amount of blood cholesterol. Increases the amount of glucose by enhancing the release of this substance from the liver.

It is an antagonist of vitamin D, therefore it flushes calcium salts from bone tissue.

Dexamethasone or Prednisolone is used to quickly relieve not only inflammatory processes, but also allergic reactions
Dexamethasone or Prednisolone is used to quickly relieve not only inflammatory processes, but also allergic reactions.

The drug is indicated for:

  • shock resistant to standard measures;
  • anaphylactic shock;
  • insufficient production of cortisol by the adrenal cortex due to a congenital disease of this organ, subacute inflammation of the thyroid gland;
  • pathologies of the adrenal axis;
  • edema of the brain caused by radiation injury, encephalitis, traumatic brain injury, tumor, neurosurgical intervention, hemorrhage and meningitis;
  • status asthmaticus;
  • pronounced narrowing of the lumen of the bronchi;
  • rheumatism;
  • severe allergic manifestations;
  • collagenoses (systemic lesions of connective tissues);
  • some malignant diseases (leukemia, lymphoma);
  • accumulation of calcium;
  • dermatosis;
  • some blood pathologies (thrombocytopenic idiopathic purpura, hemolytic anemia and agranulocytosis);
  • infectious diseases;
  • arthritis;
  • lupus erythematosus;
  • granuloma annular;
  • keloid scars.

Dexamethasone is contraindicated in:

  • pathological bleeding provoked by the use of anticoagulants;
  • joint plastic;
  • intra-articular fractures;
  • infection of the joint.

The medicine causes the following side effects:

  • metabolic disorders in the form of water retention, sodium, excessive excretion of potassium, increased appetite and deposition of excess subcutaneous fat;
  • intense blood clots;
  • arrhythmia, progression of heart failure;
  • digestive disorders, manifested in the form of nausea, an increase in the size of the liver, the appearance of ulcers on the mucous membrane of the stomach and intestines;
  • increased fatigue;
  • changes in the structure of the skin;
  • the development of steroid diabetes and Itsenko-Cushing's syndrome;
  • menstrual irregularities
  • delayed sexual development in children.
Dexamethasone is contraindicated for: pathological bleeding provoked by the use of anticoagulants
Dexamethasone is contraindicated for: pathological bleeding provoked by the use of anticoagulants.

Characteristics of Prednisolone

Prednisolone has a pronounced anti-allergic, immunosuppressive, anti-shock and anti-inflammatory effect. In large doses, it reduces the intensity of the inflammatory process by inhibiting its proliferative phase and accelerating the processes of protein breakdown. Inhibits the development of lymphocytes.

Prednisolone stimulates the synthesis of proteins in the liver tissues and the inactivation of toxic products. Increases the stability of cell membranes. Stimulates the release of glucose into the blood. Inhibits the production of thyroid-stimulating and follicle-stimulating hormones. In high quantities, it increases the threshold of excitability of brain tissue.

In some patients, this drug activates excess synthesis of hydrochloric acid in the stomach.

Shown at:

  • lupus;
  • thrombocytopenic purpura;
  • leukemia;
  • agranulocytosis;
  • eczema and exudative erythema multiforme;
  • pemphigus;
  • psoriasis;
  • baldness;
  • adrenogenital syndrome;
  • shock and emergency conditions;
  • hepatic coma;
  • hypoglycemia.

In the form of intra-articular injections, it is indicated for chronic polyarthritis, osteoarthritis of large joints, rheumatoid arthritis, arthrosis.

Prednisolone is contraindicated in:

  • hypersensitivity to prednisolone;
  • Itsenko-Cushing's disease;
  • tendency to thromboembolism;
  • viral infectious diseases;
  • period of vaccination;
  • cataract;
  • glaucoma;
  • active form of tuberculosis;
  • decompensated diabetes mellitus;
  • psychosis;
  • herpes;
  • syphilis;
  • severe myopathy;
  • polio;
  • systemic mycosis.

Side effects of Prednisolone are the same as that of Dexamethasone. In some patients, the drug provokes the occurrence of:

  • increased irritability;
  • amnesia;
  • disturbances of consciousness;
  • temperature rise;
  • depression and suicidal tendencies;
  • a sharp increase in blood pressure.
Side effects of Prednisolone: ​​increased irritability, amnesia
Side effects of Prednisolone: ​​irritability, amnesia.

With an abrupt cessation of treatment, a withdrawal syndrome is observed. Patients are worried about headache, nausea, soreness in the abdominal region, rhinitis, conjunctivitis, severe mental disorders.

Comparison of Dexamethasone and Prednisolone

Comparison of the features of taking glucocorticosteroids shows that they are powerful agents in severe and urgent conditions. Although drugs are in the same group, they are not the same thing. Prednisolone is not an analogue of Dexamethasone.

Similarity

Medicines are classified as glucocorticosteroids. They have similar actions and uses. Both drugs are used intramuscularly, intraarticularly, or intravenously. The dosage depends on the severity of the pathology. An increase in the maximum daily dose (up to 390 mg) is determined by the doctor in the absence of treatment results.

General characteristics of drugs:

  • have high activity;
  • have anti-inflammatory effects;
  • relieve manifestations of allergies;
  • suppress immunity;
  • have an anti-toxic effect;
  • used in emergency shock therapy;
  • not prescribed during pregnancy.

Differences

The difference between the tools is as follows:

  1. Prednisolone is active for 1-1.5 days, while Dexamethasone is active for up to 4 days.
  2. Prednisolone has a weaker effect.
  3. Prednisolone has more side effects.
  4. They act differently on water-salt metabolism.
  5. Dexamethasone inhibits the activity of vitamin D.

Which is stronger?

Clinical studies show that Prednisolone is 7 times weaker than Dexamethasone and 10 times weaker than Betamethasone. This ratio is taken into account when dosage recalculation is necessary.

Which is cheaper?

The cost of 3 ampoules of Prednisolone 1 ml is 33 rubles. The price of 100 tablets of the same drug, 5 mg each, is 100 rubles.

The price of 25 ampoules of Dexamethasone is 125 rubles. The cost of 10 Dexamethasone tablets is 44 rubles.

What is Dexamethasone or Prednisolone better?

It is impossible to answer unequivocally which of these drugs is better without analyzing the patient's history. The choice of medication is carried out by the doctor based on the results of the diagnostic examination. Each of the drugs has a different dosage, if taken incorrectly, the effect will not come. It is necessary to study the compatibility of each of the drugs when choosing the optimal dose. The equivalent doses are selected by the doctor.

With osteochondrosis

For relief of pain caused by the inflammatory effect, it is better to prescribe Dexamethasone. Prednisolone in this case is used much less frequently.

For allergies

Dexamethasone for allergies is used if therapy with other drugs is ineffective. In most cases, this medication has a quick and strong enough effect.

With severe allergic reactions, the effect of Prednisolone is weak. Therefore, experts recommend starting treatment with Dexamethasone.

With asthma

In case of an asthma attack, doctors prescribe either Prednisolone or Dexamethasone. If long-term therapy is necessary, Dexamethasone is preferred.

In sports

Due to the action of Dexamethasone, the intensity of anabolism increases. Taking small doses of this drug (subject to intense training) provides a steady increase in muscle mass.

The minimum dosage of Prednisolone is 0.5-1.5 mg per day.

Can the drugs be taken together?

It is absolutely impossible to take both medicines at the same time.

Can you replace each other?

In some cases, Prednisolone can be replaced with Dexamethasone, because the effect of this drug lasts longer, which allows you to take it less often. This measure makes it possible to maintain the therapeutic effect and reduce the likelihood of adverse reactions.

Reviews of doctors Dexamethasone and Prednisolone

Irina, therapist, 55 years old, Moscow: “For acute and urgent conditions associated with shock and allergies, I prescribe Dexamethasone to patients. This drug quickly relieves the symptoms of shock. Most often, a few minutes after the IV injection, signs of improvement are visible. If the injection is ineffective, I additionally use an intravenous infusion of the drug solution. Patients tolerate treatment with Dexamethasone well, there were no side effects with this therapy. "

Claudia, therapist, 50 years old, St. Petersburg: “I prescribe Dexamethasone to patients with acute forms of allergy. Due to the fact that this drug reduces the activity of the immune system, I can get a lasting therapeutic effect. The drug helps prevent the development of an immune response and life-threatening complications. When used correctly, Prednisolone does not cause side effects. "

Patient reviews

Irina, 25 years old, Moscow: “With the help of Prednisolone, it is possible to prevent the development of an allergic reaction during the flowering of garden and meadow flowers. Every spring I come across a problem - rhinitis and bronchitis while plant pollen is in the air. Prednisolone tablets help you feel much better. There were no adverse reactions while taking the drug. "

Alena, 49 years old, Syzran: “Dexamethasone is a drug that helped get rid of unbearable pain due to osteochondrosis. I make intramuscular injections of the medicine and after 20 minutes I feel relief and pain relief. The medicine also helps to get rid of inflammation in the joints, due to which pains develop much less frequently. There were no side effects from the treatment. "

Ulyana, 40 years old, Pskov: “With the help of Prednisolone it is possible to control psoriasis. The pills reduced the symptoms of this disease and improved the condition of the skin. And with the help of sunbathing, it was possible to reduce the manifestations of this pathology to a minimum. I take the drug during an exacerbation. No undesirable effects were observed from it. "

Dexamethasone and Prednisolone are classified as glucocorticosteroids of synthetic origin. The first has immunosuppressive, anti-toxic, desensitizing, anti-shock, anti-allergic and anti-inflammatory properties. Its active ingredient quickly penetrates the central nervous system. Prednisolone is a hormonal medication that has a local and systemic effect on the patient's body. dexamethasoneDexamethasone is used for cerebral edema and visual pathologies. In the latter case, the specified medication is combined with tobramycin. This glucocorticosteroid is on the list of the most important drugs. With regular intake of Dexamethasone, the sensitivity of the protein compounds that form the outer membrane to the influence of endogenous catecholamines increases.

The patient's well-being is improved by:

  • regulation of metabolic exchange;
  • a decrease in the concentration of globulins;
  • acceleration of albumin synthesis.

Dexamethasone affects the rate of absorption of all vital elements. This leads to the activation of the process of insulin production. The negative effects of Dexamethasone are reflected in water-electrolyte metabolism.

This effect is absent when using Prednisolone. This medicine is characterized by anti-toxic, anti-exudative, anti-allergic, anti-shock and anti-inflammatory effects. Prednisolone is marketed as a solution, eye drops, ointment and tablets for oral administration.

The composition of the medication depends on the form of release. Prednisolone ampoules contain: prednisone

  • active substance;
  • water for injection;
  • additive E223;
  • sodium hydroxide;
  • edetate disodium;
  • nicotinamide.

The tablets consist of an active ingredient and additional substances. Prednisolone in the form of an ointment also consists of an active substance, purified water, white paraffin and stearic acid.

Indications

Dexamethasone is prescribed for the following pathologies:

cerebral edema
Cerebral edema
  • swelling of the brain;
  • hypothyroidism;
  • oncology;
  • ophthalmopathy;
  • eczema in the acute phase;
  • agranulocytosis;
  • Addison-Birmer disease;
  • anemia of an autoimmune nature;
  • bronchial asthma.

Prednisolone has a positive effect on the condition of patients suffering from hepatitis, lung cancer, status asthmaticus, tuberculous meningitis. The spectrum of action of this medication is quite wide. It is also used in the presence of allergic ailments, skin diseases, multiple sclerosis, inflammatory pathologies of the gastrointestinal tract. In any case, the therapeutic regimen is prescribed only by the attending physician. Self-medication is strictly prohibited.

Contraindications

Prednisolone and Dexamethasone cannot be included in the list of medications used if the patient suffers from hypersensitivity to the components of the composition. Particular care should be taken with such ailments as:

peptic ulcer
Ulcerative disease
  • peptic disease;
  • diverticulitis;
  • gastritis;
  • anastomosis of the intestine;
  • systemic osteoporosis;
  • immunodeficiency.

The risk of negative consequences when taking dexamethasone is elevated if the patient's history is present by the pathology of endocrine and cardiovascular systems. A significant reason for concern is parasite infection. Dexamethasone is not recommended to drink (introduce) during pregnancy, during lactation. Another restriction can be a children's age.

Prednisolone also has "special" contraindications, among them:

tuberculosis
Tuberculosis
  • tuberculosis;
  • kidney inflammation;
  • Incenko-Cushing disease;
  • syphilis;
  • Sugar diabetes (regardless of type).

In the risk group, the elderly, minor patients.

The main differences

Prednisolone and Dexamethasone have a number of differences. None of them can be ignored when choosing drug therapy. The difference between these drugs is as follows:

  1. The duration of the effect. Prednisolone works for 24-36 hours. Dexamethasone has a beneficial effect for several days.
  2. Impact strength. Dexamethasone affects the focus of inflammation more strongly than Prednisolone.
  3. Changes in water-salt metabolism. Dexamethasone is considered a safer medication. It does not cause electrolyte imbalances.

The list is supplemented by the mechanism of action and adverse reactions.

If a child or an adult needs hormone therapy, Prednisolone is most often prescribed. The choice is due to the duration of the half-life. Dexamethasone is a fluoridated drug that has a teratogenic effect.

What are the similarities

Prednisolone and Dexamethasone are not complete analogues. Despite this, they are classified as one pharmacological group. Synthetic glucocorticosteroids are substitutes for a hormone produced in the adrenal cortex.

an injectionBoth drugs are broad-spectrum. The etiology of the inflammatory process in this case does not matter. The relief of foci of inflammation occurs due to a slowdown in the production of prostaglandins and other substances that enhance blood microcirculation.

Dexamethasone and Prednisolone have a positive effect on allergies. They inhibit the release of histamine. The list of indications for use of Prednisolone and Dexamethasone is also similar. Synthetic glucocorticosteroids break down in the liver.

Which drug to choose

The medicinal product is selected by the attending physician. He focuses on the results of a diagnostic examination, the general condition of the patient and his individual characteristics. The dosage and the procedure for taking are determined, taking into account the severity of the disease and the frequency of attacks. The release form also requires attention. If the patient needs long-term therapy, he is prescribed medication in the form of tablets. To achieve the desired effect, injection solutions are used.

Side effects

Dexamethasone and Prednisolone can provoke the appearance of many adverse reactions, among them;

  • disruptions in the work of the adrenal glands;
  • decreased tolerance to sugars;
  • the progression of diabetes mellitus;
  • problems with the withdrawal and absorption of potassium, calcium and sodium;
  • excess weight;
  • excessive sweating.

The appearance of such negative consequences as:

flatulence
Flatulence
  • a sharp increase in intracranial and blood pressure;
  • dyspepsia, flatulence;
  • erosive esophagitis;
  • convulsive syndrome.

The list can be supplemented with unreasonable anxiety, hiccups, severe headaches, pancreatitis.

Prednisolone causes acne, diseases of the musculoskeletal system, pathological changes in the musculoskeletal system, organs of vision. In a patient taking Prednisolone, symptoms are often accompanied by:

  • loss of orientation in space;
  • sleep problems;
  • peripheral edema.

In children, after undergoing therapy, which includes Prednisolone or Dexamethasone, delayed sexual development often occurs. In case of violation of the order of admission, the clinical picture is supplemented by painful sensations in the joints, excessive nervousness, manic-depressive psychosis, arrhythmia and muscle atrophy.

angioedema
Quincke's edema

If the dosage is excessively exceeded, anaphylactic shock, Quincke's edema, itching and rashes on the skin may develop. These symptoms indicate an allergic reaction. When taking Dexamethasone and Prednisolone, one must not forget about the withdrawal syndrome.

With this phenomenon, general malaise, loss of appetite, chronic fatigue, and exacerbation of the disease occur. Ignoring clinical manifestations is fraught with the development of collapse and hypoadrenal crisis. If untreated, death is possible. Acute cardiovascular failure can be a factor provoking complete dysfunction of internal organs.

- Family clinic OPORA, Yekaterinburg

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